ParkinsonCanadaV1, Main, Exploration, bibRecord, 002065

Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder

Identifieur interne : 002065 ( Main/Exploration ); précédent : 002064; suivant : 002066

Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder

Auteurs : R. B. Postuma [Canada] ; J. F. Gagnon [Canada] ; M. Vendette [Canada] ; M. L. Fantini [Italie] ; J. Massicotte-Marquez [Canada] ; J. Montplaisir [Canada]

Source :

Neurology [ 0028-3878 ] ; 2009.

RBID : Pascal:09-0205351

Descripteurs français

Pascal (Inist)
- Trouble du sommeil, Pathologie du système nerveux, Facteur risque, Idiopathique, Sommeil paradoxal, Comportement.

English descriptors

KwdEn :
- Aged, Behavior, Dementia (epidemiology), Female, Follow-Up Studies, Humans, Idiopathic, Lewy Body Disease (epidemiology), Life Tables, Male, Middle Aged, Multiple System Atrophy (epidemiology), Nervous system diseases, Neurodegenerative Diseases (epidemiology), Neurodegenerative Diseases (etiology), Neurodegenerative Diseases (psychology), Neuropsychological Tests, Parkinson Disease (epidemiology), Polysomnography, Psychiatric Status Rating Scales, REM Sleep Behavior Disorder (complications), REM Sleep Behavior Disorder (epidemiology), REM Sleep Behavior Disorder (psychology), Rapid eye movement sleep, Risk, Risk factor, Sleep disorder, Survival Analysis.
MESH :
- complications : REM Sleep Behavior Disorder.
- epidemiology : Dementia, Lewy Body Disease, Multiple System Atrophy, Neurodegenerative Diseases, Parkinson Disease, REM Sleep Behavior Disorder.
- etiology : Neurodegenerative Diseases.
- psychology : Neurodegenerative Diseases, REM Sleep Behavior Disorder.
- Aged, Female, Follow-Up Studies, Humans, Life Tables, Male, Middle Aged, Neuropsychological Tests, Polysomnography, Psychiatric Status Rating Scales, Risk, Survival Analysis.

Abstract

Objective: Idiopathic REM sleep behavior disorder (RBD) is a potential preclinical marker for the development of neurodegenerative diseases, particularly Parkinson disease (PD) and Lewy body dementia. However, the long-term risk of developing neurodegeneration in patients with idiopathic RBD has not been established. Obtaining an accurate picture of this risk is essential for counseling patients and for development of potential neuroprotective therapies. Methods: We conducted a follow-up study of all patients seen at the sleep disorders laboratory at the Hôpital du Sacré Coeur with a diagnosis of idiopathic RBD. Diagnoses of parkinsonism and dementia were defined according to standard criteria. Survival curves were constructed to estimate the 5-, 10-, and 12-year risk of developing neurodegenerative disease. Results: Of 113 patients, 93 (82%) met inclusion criteria. The mean age of participants was 65.4 years and 75 patients (80.4%) were men. Over the follow-up period, 26/93 patients developed a neurodegenerative disorder. A total of 14 patients developed PD, 7 developed Lewy body dementia, 4 developed dementia that met clinical criteria for AD, and 1 developed multiple system atrophy. The estimated 5-year risk of neurodegenerative disease was 17.7%, the 10-year risk was 40.6%, and the 12-year risk was 52.4%. Conclusions: Although we have found a slightly lower risk than other reports, the risk of developing neurodegenerative disease in idiopathic REM sleep behavior disorder is substantial, with the majority of patients developing Parkinson disease and Lewy body dementia.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828948

Affiliations:

Le document en format XML

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<term>Humans</term>
<term>Idiopathic</term>
<term>Lewy Body Disease (epidemiology)</term>
<term>Life Tables</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multiple System Atrophy (epidemiology)</term>
<term>Nervous system diseases</term>
<term>Neurodegenerative Diseases (epidemiology)</term>
<term>Neurodegenerative Diseases (etiology)</term>
<term>Neurodegenerative Diseases (psychology)</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Polysomnography</term>
<term>Psychiatric Status Rating Scales</term>
<term>REM Sleep Behavior Disorder (complications)</term>
<term>REM Sleep Behavior Disorder (epidemiology)</term>
<term>REM Sleep Behavior Disorder (psychology)</term>
<term>Rapid eye movement sleep</term>
<term>Risk</term>
<term>Risk factor</term>
<term>Sleep disorder</term>
<term>Survival Analysis</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>REM Sleep Behavior Disorder</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dementia</term>
<term>Lewy Body Disease</term>
<term>Multiple System Atrophy</term>
<term>Neurodegenerative Diseases</term>
<term>Parkinson Disease</term>
<term>REM Sleep Behavior Disorder</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Neurodegenerative Diseases</term>
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<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Objective: Idiopathic REM sleep behavior disorder (RBD) is a potential preclinical marker for the development of neurodegenerative diseases, particularly Parkinson disease (PD) and Lewy body dementia. However, the long-term risk of developing neurodegeneration in patients with idiopathic RBD has not been established. Obtaining an accurate picture of this risk is essential for counseling patients and for development of potential neuroprotective therapies. Methods: We conducted a follow-up study of all patients seen at the sleep disorders laboratory at the Hôpital du Sacré Coeur with a diagnosis of idiopathic RBD. Diagnoses of parkinsonism and dementia were defined according to standard criteria. Survival curves were constructed to estimate the 5-, 10-, and 12-year risk of developing neurodegenerative disease. Results: Of 113 patients, 93 (82%) met inclusion criteria. The mean age of participants was 65.4 years and 75 patients (80.4%) were men. Over the follow-up period, 26/93 patients developed a neurodegenerative disorder. A total of 14 patients developed PD, 7 developed Lewy body dementia, 4 developed dementia that met clinical criteria for AD, and 1 developed multiple system atrophy. The estimated 5-year risk of neurodegenerative disease was 17.7%, the 10-year risk was 40.6%, and the 12-year risk was 52.4%. Conclusions: Although we have found a slightly lower risk than other reports, the risk of developing neurodegenerative disease in idiopathic REM sleep behavior disorder is substantial, with the majority of patients developing Parkinson disease and Lewy body dementia.</div>
</front>
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<li>Italie</li>
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<li>Québec</li>
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<tree><country name="Canada"><region name="Québec"><name sortKey="Postuma, R B" sort="Postuma, R B" uniqKey="Postuma R" first="R. B." last="Postuma">R. B. Postuma</name>
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<name sortKey="Vendette, M" sort="Vendette, M" uniqKey="Vendette M" first="M." last="Vendette">M. Vendette</name>
</country>
<country name="Italie"><region name="Lombardie"><name sortKey="Fantini, M L" sort="Fantini, M L" uniqKey="Fantini M" first="M. L." last="Fantini">M. L. Fantini</name>
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La maladie de Parkinson au Canada (serveur d'exploration)

Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder

Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder

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	La maladie de Parkinson au Canada (serveur d'exploration)
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